Eighty-five per cent of all BCCs appear on the head and neck region.9,10 Risk factors are fair skin, tendency to freckle,11 degree of sun exposure,12-14 excessive sunbed use, radiotherapy, phototherapy, male sex, and a genetic predisposition.15 Naevoid BCC syndrome (Gorlin syndrome) is an autosomal dominantly inherited condition characterised by developmental abnormalities and the occurrence of multiple BCCs. Mutations in patients with naevoid BCC syndrome has been found on the patched gene located on chromosome 9, which appears to be crucial for proper embryonic development and for tumour suppression.16

0 0

Post a comment