In moderate climates, the primary pathogen in non-bullous impetigo is Staphylococcus aureus.

However, in warm and humid climates Streptococcus pyogenes or both S. pyogenes and S. aureus are more often isolated. The relative frequency of S. aureus infections has also changed with time. It was predominant in the 1940s and 1950s, then group-A streptococci became more prevalent. Recently S. aureus has become more common again.4 Bullous impetigo is a staphylococcal disease.

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