The dermatophytes most frequently reported in clinical trials to be present on patients' skin at trial entry are Trichophyton rubrum, T. mentagrophytes, Epidermophyton floccosum and T. interdigitale.4

Scaling, fissuring, pruritus and itching are some of the clinical features of fungal infections of the skin and it is these irritations that make the patient seek treatment. The natural history of the condition if untreated is a chronic, worsening infection which can lead to fissuring and breaks in the epidermis. Although the condition will not resolve spontaneously, some evidence from cure rates collected from people in the placebo arms of controlled trials suggests that improved foot hygiene alone may cure the infection in a proportion of people.5,6

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