SJS-TEN is essentially drug induced (70-90% of cases). Graft versus host disease is another well-established aetiology, independent of drugs. A few cases are related to infection (Mycoplasma pneumoniae); other cases remain unexplained ("idiopathic" forms). The most extensive study of medication use and SJS-TEN pointed mainly to sulfonamides, anticonvulsant agents, non-steroidal anti-inflammatory drugs, allopurinol and chlormezanone.4 HIV infection dramatically increases the risk. A predisposing effect of autoimmune disorders, such as lupus, and an HLA-linked genetic susceptibility have been also suggested.
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