Aetiologyrisk factors

Immediate cutaneous reactions to insect bites are mediated by antisaliva IgE induced by the injection of the insect saliva.12 Reactions to Hymenoptera stings are caused by the venom of the stinging insect and can be either toxic (local reaction) or allergic (large local reaction, mild or severe systemic reaction). Patients who have been diagnosed with hypersensitivity to Hymenoptera venoms (positive skin-prick test and/or presence of specific IgE) as well as patients with a previous history of systemic reactions to Hymenoptera stings are at higher risk for systemic allergic reactions than non-sensitised subjects.1,13-25

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