In the UK and North America, AIDS-related KS is the most common variant. In this group, where overall prognosis is often determined by other complications such as opportunistic infections, treatment aims to improve the cosmetic appearance of cutaneous disease and palliate symptoms associated with lymph node or visceral disease (such as oedema, bleeding and shortness of breath), with minimal toxicity. However, the introduction of HAART and more effective prophylaxis of opportunistic infections is modifying the natural history of HIV infection and delaying progression to AIDS. Other endpoints such as time to treatment failure and overall survival may become more important in the future in this group of patients with KS.
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