Background Definition

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are variants of the same process, presenting as severe mucosal erosions with widespread purpuric cutaneous macules (atypical targets), often confluent with positive Nikolsky's sign and epidermal detachment. In SJS, epidermal detachment involves less than 10% of total body skin area; transitional SJS-TEN is defined by an epidermal detachment between 10% and 30%, and TEN by a detachment greater than 30%. A full-thickness epidermal necrosis is observed on pathological examination.

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