The term "hand eczema" implies an inflammation of the skin (dermatitis) that is confined to the hands. Clinically, the condition is characterised by signs of redness, vesicles (tiny blisters), papules, scaling, cracks and hyperkeratosis (callous-like thickening), all of which may be present at different points in time. Itch, sometimes severe, is a common feature. Microscopically, the disease is characterised by spongiosis with varying degrees of acanthosis, and a superficial perivascular infiltrate of lymphocytes and histiocytes.
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