Diclofenac sodium is a non-steroidal anti-inflammatory drug which has been examined for use in treatment of AK, with some success.102,103
Curaderm has been reported to completely cure (clinically and histologically) AK lesions in a mean time of 2-9 weeks (range 1-4 weeks) in an open-label Australian trial.105 However, no recent literature on this treatment was found in any searches, and no North American use has been reported.
The nucleoside tubercidin interferes with glycolysis and inhibits synthesis of DNA, RNA and proteins. Tubercidin was not effective in a case series of five patients with facial and scalp AK.104 Four of the patients showed no response of lesions to tubercidin after 4 weeks of treatment.
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