We found no RCTs or other controlled trials. We found several large observational studies with a total of 550 participants.72-75

Wright described an observational study of 76 people treated with gold and followed for 10

years.72 Participants were not identified as having DLE but appear to have had some form of chronic cutaneous lupus. Of the 76 participants, 28 were described as cured, 26 as showing marked improvement and 9 as having failed to improve. Pascher reported on 46 patients with DLE, 54% showing clearing or a marked improvement.75

An observational study reported the effect of a newer gold preparation, auranofin, in 23 people with DLE over 1 year.76 A marked improvement was seen in eight participants.

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