Clinical clearance in the 5-FU group was superior to the interferon alfa-2b group (100% versus 90%) at 8-week assessment. A statistically significant difference in histological response to treatment was further noted at 4 and 8 weeks in favour of interferon (P<0-05).78 This trial failed to specify the number of BD lesions in each treatment group; consequently, the reported data prevents conclusions for BD independent of AK.

In the uncontrolled trials, clinical clearance rates were generally high, ranging from 87%80 to 100%.49 It is noteworthy that, of studies with sufficient follow up to document recurrence (12-24 months), one study reported a significantly higher recurrence rate (20%)81 than other studies (0% and 8%).49 5880 The largest uncontrolled trial (n = 41) used 5-FU (in 1-3% in propylene glycol) applied twice daily for 2-3 months.58 Clinical clearance rate in this study was 93%, with an 8% recurrence rate during a median follow up of 8 years (range: 6-121 months). The authors suggest that at least 2-5% 5-FU in propylene glycol is required for extrafacial sites.

The base in which 5-FU is delivered significantly affects its activity: 20% 5-FU in an ointment base, 5% 5-FU in a cream base, and 1% 5-FU in propylene glycol provide approximately equivalent cytotoxic activity.72,77,82,83 Several studies investigated ways to enhance 5-FU activity. Iontophoresis does not appear to improve 5-FU activity when compared with 5-FU alone.49,58,80,81 Application under occlusion, pretreatment with keratolytic agents, or deliberate exposure to sunlight (photosensitivity effect of 5-FU) are anecdotally reported as enhancement techniques.58

Was this article helpful?

0 0
Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

Get My Free Ebook

Post a comment