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We found no systematic reviews. We found one RCT that involved small numbers of children. Tosti et al.17 compared SADBE, diphencyprone, minoxidil and placebo, finding a significant relationship between the age of the patients and the results. Complete hair regrowth was seen in 7V3% of adults, but only 38-9% of children.

We found two case series. Schuttelaar et al50 treated 26 children with diphencyprone weekly for a period of 3-12 months. Sixteen subjects had alopecia areata totalis, the others having patchy disease only. Eighty-four per cent of children showed hair regrowth, 32% of the total being cosmetically acceptable. Where treatment failed (0-5% hair growth), it was recommended not to continue treatment for longer than 1 year as hair growth is not promoted by continued treatment. Orecchia et al.51 treated 28 unresponsive children under the age of 13 years with SADBE for 12 months. Thirty-two per cent of patients achieved complete or cosmetically acceptable regrowth and a further 21% achieved significant regrowth.

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