Quality of evidence: I
We found no systematic reviews, one RCT and one unblinded controlled trial. The RCT investigated 61 lower leg lesions to compare the efficacy of green light and red light wavelengths after incubation with 20% 5-ALA for 4 hours.93 The follow up period was 12 months. The unblinded, controlled trial investigated 40 lesions to determine the relative efficacy of 20% 5-ALA cream and a modified portable desktop lamp against cryotherapy.94 The method of randomisation in this study was not specified. The follow up period was 12 months.
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