Bowens disease

Quality of evidence: Il-i

We found no systematic reviews and no RCTs. We found one small unblinded quasi-randomised controlled trial comparing topical 5% 5-FU cream with intralesional interferon alfa-2b (1 000 000 units/injection) for both BD and AK.78 The treatment-allocation method was not specified. Ten lesions of BD and AK were allocated to each group, and clinical clearance and histological change were assessed at 1 and 2 months' follow up. We found five uncontrolled trials addressing the therapeutic efficacy of

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