Box 331 The quality of evidence scale system employed by Cox and colleagues147

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I Evidence obtained from at least one properly designed randomised control trial

Il-i Evidence obtained from well-designed controlled trials without randomisation ll-ii Evidence obtained from well-designed cohort or case-control analytic studies, preferably from more than one centre or research group ll-iii Evidence obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled experiments could also be included

III Options of respected authorities based on clinical experience, descriptive studies or reports of expert committees

IV Evidence inadequate owing to problems of methodology (for example sample size, length of comprehensiveness of follow up or conflicts in evidence)


What is the role of oral antifungal therapy in the management of dermatophyte onychomycosis in adults?

One double-blind RCT compared griseofulvin, 500 mg/day for 12 weeks, with terbinafine in the treatment of onychomycosis (Table 33.1).141 The mycological cure rate and complete cure rate were 63% and 39%, respectively.

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