We found no systematic reviews or RCTs for oral ciclosporin. In a small case series, six patients received oral ciclosporin, 6 mg/kg/day for 12 weeks.45 All patients had some regrowth, however cosmetically acceptable regrowth occurred in only two of five patients with alopecia totalis/universalis and in the single patient with patchy alopecia areata. All patients had relapsed within 3 months of stopping therapy. A randomised study of 26 patients with alopecia totalis or universalis compared topical 10% ciclosporin daily with photochemotherapy three times a week and intravenous thymopentin, 50 mg three times a week every 3 months over 9 months.23 All patients had previously been unresponsive to sensitising therapy for at least 12 months. None of the patients in the study had any cosmetic clinical improvement by the end of the study.
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