The immunosuppressive drug ciclosporin has been used for treating severe psoriasis since the early 1980s. One systematic review concluded that ciclosporin is more effective at inducing remission at 5 mg/kg/day than at 2-5 mg/kg/day.59 Further increases in the dose produce little extra benefit and are limited by side-effects, particularly on renal function. Continuous therapy is usually required to maintain remission; furthermore, doses below 2-5 mg/kg/day appear to be insufficient to achieve this. Ciclosporin appears to be more effective than etretinate. It appears to achieve more rapid improvement of psoriasis than methotrexate but produces similar benefit by 16 weeks.
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.