Griseofulvin was the first systemic agent used to treat onychomycosis on a widespread basis. The newer oral agents (itraconazole, terbinafine and fluconazole) have been found to be more effective than griseofulvin and the duration of active therapy is also shorter with the more recently introduced antimycotics.151,152 Moreover, when griseofulvin is used to treat dermatophyte toenail onychomycosis, relapse rates may be higher (40-60%)129 than with the newer oral antifungal agents.33,153-156

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