Comment

The analysis of each of these studies comparing PUVA with UVB (narrow band and broad band) as prophylactic therapies for PLE took into account polysulphone-badge-determined natural UV exposure after the treatment courses. Even with randomisation (methods for which were not defined in either paper), differences in subsequent sunlight seeking or avoidance behaviour in the groups compared could have influenced findings. Insufficient raw data are presented to allow retrospective calculations of the power of either study. Nevertheless, it can be safely concluded that PUVA is not much more effective than TL-01 UVB, and may even be less effective.

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