Fluconazole is effective and safe for the treatment of onychomycosis. Compared with terbinafine and itraconazole, there are relatively few studies that have evaluated the efficacy of fluconazole in the treatment of toenail onychomycosis. The preferred regimen for fluconazole is once weekly therapy, typically 150 mg per week for several months until the abnormal-appearing nail plate has grown out. In the study reported by Scher et a/.34 the clinical relapse rate over a 6-month follow up was 4-4%.153 Studies evaluating the use of once-weekly fluconazole at a higher doses such as 300 mg or 450 mg once weekly34,137 or continuous fluconazole administration have not been discussed.

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