Comment

Despite a marked lack of supporting evidence, one of the tenets of good wound care, at least in the US, is supplementary vitamin C and zinc. This is largely a result of the relatively benign nature of these treatments, as well as their modest cost.

No studies have effectively evaluated the role of daily multivitamins in patients with chronic wounds. Another unexplored therapy is iron supplementation. An adequate tissue iron level is needed for appropriate metabolic functioning, and indeed mildly decreased iron levels may be associated with hair loss.34 Since granulation tissue represents an environment of rapid cell proliferation, it is possible that wound healing may be sensitive to mildly decreased levels of iron, although this has yet to be demonstrated.

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