Comment

The study referred to allowed for the continuation of hydroxyurea therapy in an open assessment.95 The authors commented that it took 6 weeks for maximal improvement to be achieved. Hydroxyurea has been used for treating psoriasis for nearly 30 years. The fact that it has not been nearly so widely used as other treatment modalities and that it has been seen necessary to use it in combination with other powerful antipsoriatic drugs suggest that dermatologists have not found it very effective compared with treatments such as methotrexate, ciclosporin or photochemotherapy (PUVA). The available data do not allow a direct comparison with these treatments. Nevertheless there is some evidence that individual patients may respond well. Hydroxyurea has the advantage that it may be possible to use it in circumstances where other treatments are contraindicated.

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