No trial used time to relapse as the outcome variable. No study gave a rationale for the sample size, which was between 15 and 30 patients. None of the trials stated explicitly which conventional topical therapy was the comparator; at best it was described as steroids and/or tar. Overall, the studies did not explicitly describe the types of hand eczema of the patients: four studies specified the type of eczema as constitutional11,14-16; the other two gave only very partial results among some types of hand eczema.12,13 Older literature may give an indication about possible long-term harm.
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