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We found no RCTs for the treatment of perioral dermatitis with oxytetracycline. Similarly, we found no placebo-controlled trials using oxytetracyclines to treat perioral dermatitis. All the studies looking at the treatment of perioral dermatitis with oxytetracycline were methodologically flawed. For example, in one study patients were randomised to three groups of treatment but only mild cases were assigned to one treatment group. With the lack of quality evidence available, it is difficult to determine the efficacy of oxytetracycline in the treatment of perioral dermatitis.

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