Comment

The methods of randomisation and blinding were not clearly described in either RCT.22,32 No intention-to-treat analysis was done in these studies but the dropout rates were 3/3522 and 5/60.32 One of the RCTs22 was funded by the manufacturer of itraconazole. In one uncontrolled study46 that reported a complete cure rate of 40%, the high dropout rate of 54% may have artificially decreased the response rate because those who are cured may be less likely to return for follow up. I found much information from uncontrolled studies but additional RCTs comparing itraconazole with other antifungals are clearly needed.

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