The studies evaluating the potential effect of low-level laser therapy for the treatment of venous ulcers included a total of only 139 patients. Moreover, the types of laser, power and duration of follow up varied across the studies. Some of these studies used very short endpoints, and it is possible that potential benefits were missed because the studies failed to follow patients for long enough. Moreover, there is some suggestion that laser therapy may have an effect on endpoints other than chance of healing, for example pain at the wound site and the amount of granulation tissue,38 although this remains an area in need of further investigation.

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