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We found only two controlled trials, one of them randomised, on the use of antimalarials for DLE. The RCT was flawed by the short duration and by the inclusion of people with SCLE in unequal numbers in the two study groups. We found three RCTs of chloroquine in mild SLE, but little information about skin lesions was reported. The older observational studies lacked a parallel control group but patients were carefully followed up for longer and included large numbers of people. Dosage tended to be unacceptably high by current standards. We have not found evidence of a difference between hydroxychloroquine and chloroquine in the treatment of cutaneous lupus or any information on this disorder regarding dosage in relation to either efficacy or toxicity.

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