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PDT appears promising for BD but there were two major flaws in the study design. First, investigators were not blinded to the type of light used, thus potentially introducing bias. Although more objective outcomes such as clinical clearance and recurrence are unsusceptible to bias related to lack of blinding, the validity of the results concerning treatment-related pain may be improved with blinding. The analysis did not follow an ITT analysis, as 13% of initially randomised lesions (nine of 61) were excluded from the final analysis, thus risking overestimation of efficacy and underestimation of recurrence.

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