Comments

All studies were randomised but method and concealment of allocation were not described. All were described as double-blind, except Latchman et al.,29 where no blinding was mentioned. No ITT analysis was carried out. It is also questionable whether the placebo plants were truly inert. The study by Sheehan et al26 reported large effects in children, highlighting a promising treatment of atopic eczema. This has not been replicated in the other studies, although they are all quite similar. Clearly larger scale RCTs of longer duration are needed.

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