Risk of infection, bleeding and other tissue damage is inherent in any autologous skin grafting procedure. Moreover, there is always an inherent risk that the donor site will prove difficult to heal as well.

Using cultured autologous keratinocytes is likely to delay of treatment because it takes several weeks for the cells to be cultured. Moreover, patients need to undergo a skin biopsy in order to provide the laboratory with the necessary cells.11

Artificial skin theoretically could be cultured from samples that are infected with viruses, including HIV. Given the aggressive screening associated with this harvesting, however, the chance of infection is remote, although it does remain a possibility that the allogeneic human cells were taken from an HIV-positive but seronegative donor.17

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