Cryotherapy

Three RCTs were found and are summarised in Table 26.2. One study of 93 patients compared radiotherapy with cryotherapy for primary BCC excluding lesions on the nose or pinna.28 The aims of the study were to compare the control of the tumours with the two treatments, to assess the final cosmetic result and to compare the discomfort and inconvenience experienced by the

Table 26.1 Randomised controlled trials evaluating surgical excision in the treatment of basal cell carcinoma

Study

Method

Participants

Interventions

Outcomes

Notes

Table 26.1 Randomised controlled trials evaluating surgical excision in the treatment of basal cell carcinoma

Study

Method

Participants

Interventions

Outcomes

Notes

Avril et al Single centre

HP BCCs

T1: surgery - resection

FU: 3, 6, 12 months

Ex: BCC on scalp

199725 (France) Randomisation by

T1: 174, T2: 173

of whole tumour with a

after end of treatment:

or neck, patients

sequential sealed

patients

free margin of at least

then yearly until fourth

who had total

envelopes

Histological type T1:

2 mm from visible

year

removal of BCC

ITT

79 N, 52 ulcerated,

borders; T2:

Rate of histologically

at biopsy, with

36 S and pagetoid,

radiotherapy -

confirmed persistent

5 or more BCCs,

7 sclerosing; T2: 74 N,

interstitial

tumour or recurrence

life expectancy

50 ulcerated, 41 S and

brachytherapy,

after 4 years

<3 years

pagetoid, 8 sclerosing

superficial contract

Patients examined by

Location T1: 53 nose,

therapy or

dermatologists:

36 eyelids,

conventional therapy,

photographs of scar

36 forehead, 10 chin,

chosen by

taken at three

5 ear; T2: 49 nose,

radiotherapist

standardised

42 cheek, 35 eyelids,

according to tumour

distances

29 forehead, 12 chin,

parameters and

6 ear

location and patient characteristics

BCC, basal cell carcinoma; HP, histologically proven; BP, biopsy proven; MU, mega units; IFN, interferons; Ex, exclusion; T1/2/3, treatment groups 1/2/3; FU, follow up; 5-FU/epi, 5-fluorouracil/epinephrine; PC, phosphatidyl choline; PDT, photodynamic therapy; ALA, gamma-aminolevulinic acid; N, nodular; S, Superficial; M, morphea-like; PP, per protocol; ITT, intention to treat

BCC, basal cell carcinoma; HP, histologically proven; BP, biopsy proven; MU, mega units; IFN, interferons; Ex, exclusion; T1/2/3, treatment groups 1/2/3; FU, follow up; 5-FU/epi, 5-fluorouracil/epinephrine; PC, phosphatidyl choline; PDT, photodynamic therapy; ALA, gamma-aminolevulinic acid; N, nodular; S, Superficial; M, morphea-like; PP, per protocol; ITT, intention to treat patient. Cryotherapy consisted of two freeze-thaw cycles, freezing for 1 minute each time.

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How To Reduce Acne Scarring

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