Dapsone

Dapsone is also reportedly effective in the treatment of mild pemphigus or as a steroid-sparing agent for maintenance therapy. The most substantial evidence in favour of dapsone therapy was reported by Basset et al.40 Nine previously untreated patients received dapsone 200-300 mg/day and were followed up for an average of 22 months. Five patients, all with mild disease, responded with at least a 50% decrease in the extent of their disease within 15 days of starting therapy. One of these patients developed haemolytic anemia and discontinued dapsone. Although there are no controls, the finding that more than half of the patients responded to treatment with dapsone alone is noteworthy and indicates that dapsone provides significant clinical benefit. This issue is being followed up in a large international RCT sponsored by the Medical Dermatology Society and Jacobus Pharmaceuticals.

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