The diagnosis of SCC relies on the histopatho-logical finding of atypical hyperproliferative keratinocytes compared with adjacent normal epidermis. Common findings include cytological and architectural disorganisation, decreased differentiation and atypical mitoses. SCC in situ is diagnosed when atypia is identified only in the epidermal compartment. Invasive SCC is distinguished from SCC in situ by the invasion of the dermis by epithelioid cells. SCC may also be classified according to the degree of differentiation, a clinically important specification since less differentiated tumours are associated with poor prognosis.
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