Drawbacks

Two patients had nausea and intense stomach ache with severe vomiting at weeks 2 and 4 of treatment and required discontinuation of therapy.22 One griseofulvin-treated patient showed a two fold increase in serum alanine aminotransferase and aspartate aminotransferase after 3 weeks of treatment but values returned to normal at the following weekly clinic visit.20

The following adverse events have been described as of uncertain relationship with the study drug: skin infections, skin infestations, raised hepatic enzymes, raised triglycerides, raised uric acid, anaemia, eosinophilia, leucocytosis and granulocytopenia.26,27 In the largest RCT,25 a total of 52 adverse events were detected in 27 patients in the griseofulvin group and including abdominal discomfort and vomiting. None was rated as severe but one patient was withdrawn from the study because of abdominal pain, headaches and vomiting. In other studies no, or no significant, adverse effects were reported.18,19,21,23,24

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