None were reported in the first two studies, with the exception of one patient who experienced a burning sensation when the oil-in-water emollient was applied.1 In the study by Hanifin et al,3 14% of the patients reported stinging or burning on the side treated with desonide compared with 12% on the side treated with the combination at week 1. Most patients (96% versus 4%) preferred the combination treatment. Transient burning was noticed in four patients treated with urea and in five patients treated with vehicle creams in the study by Wilhelm et al.4 No adverse effects were described by Andersson et al.2 Other possible side-effects of emollients include occlusion folliculitis on hair-bearing skin and accidents from slipping whilst climbing into the bath when using emollient bath additives.
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