The Japanese RCT had 10 withdrawals.35 One participant withdrew because of side-effects while 51 failed to complete the 12-week follow up. Five people in the group receiving vitamins E and C suffered side-effects: two had acne, one xerosis, one mild stomach upset and one metrorrhagia. Eight people in the vitamin E group complained of side-effects: four had acne, one stomach upset, one excessive perspiration and two menstrual abnormalities. Side-effects were reported by participants receiving vitamin C: four suffered acne, two hot flushes, one stomach upset and one seborrhoeic dermatitis.
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