All participants in the RCT27 experienced stinging and redness during and after each peeling session. One person developed an area of burn after the 20% glycolic acid peeling, resulting in a zone of hyperpigmentation which disappeared after 2 months. No significant differences between treatments were found.

Glycolic acid peelings were more frequently reported as more painful than Jessner's solution. One participant developed postinflammatory hyperpigmentation in the side receiving glycolic acid.28

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