Tolerability was considered to be good or very good in 73% of patients in the RCT using acitretin.5 Side-effects noted in this study were mainly cheilitis and dry mouth. In the study with etretinate,6 half of the patients experienced side-effects (dryness and swelling of oral mucosae, dermatitis, gastrointestinal disturbances, headache), leading to interruption of the treatment in four patients. Side-effects of systemic retinoids are not exceptional (myalgia, arthralgia, increased blood levels of cholesterol, triglycerides and aminotransferases). The most severe side-effect of retinoids is teratogenicity.

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