In Caucasian people: The first RCT described some causes for withdrawal such as cutaneous side-effects (3/25 (12% ) with tretinoin compared with 0/25 with placebo). Worsening of melasma occurred in a woman from the tretinoin group. Moderate cutaneous reactions were more frequent with tretinoin (22/25 (88%)) than with placebo (7/24 (29%)) with placebo (RR 3-0, CI 1-6-5-7; number need to harm (NNH (see Table 10.1) 1-7, CI 1-3-3-1). Severe cutaneous reactions occurred only with tretinoin (4/25 (16%); NNH 6-3).21
In Asian people: The second RCT found similar withdrawals rates in both groups (4/15 (27%) with isotretinoin compared with 3/15 (20%) with placebo).17 Mild transient erythema and/or peeling occurred only in the isotretinoin group (4/15 (27%) NNH 3-8).
In black people: The most frequently found side-effects in the third RCT were erythema and/or peeling (10/15 (67%) with tretinoin compared with 1/15 (7%) with placebo; RR 10, CI 1-5-68-7; NNH 1-7, CI 1-1-2-4) in the area of application.22
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Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.