Drawbacks

Almost all patients experienced flu-like symptoms with interferon alfa, and in the

Is interferon alfa an effective systemic treatment for AIDS-related Kaposi's sarcoma alone or in combination with zidovudine?

study of Volberding et al. 6% of patients discontinued therapy because of adverse reactions.31 In addition to flu-like symptoms, adverse events include haematological toxicity and abnormalities in liver function tests. In the randomised study of Groopman et al, mild haematological and hepatic toxicity were seen at both high and low doses of interferon alfa.28

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