Drawbacks

Topical antifungal compounds are well tolerated and are not associated with high rates of adverse events. One systematic review7 found that few trial reports gave details of adverse events and the few that were reported were not severe (for example itching, redness or burning).

The systematic review of oral treatments for fungal infections of the skin4 noted that all 12 included trials reported side-effects. All drugs produced side-effects; the rate was lowest for fluconazole (11%) and highest for terbinafine (18%). Gastrointestinal effects and rashes were reported most frequently.

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