In the randomised trial of Stelzer and Griffin, toxicity was graded using the Radiation Therapy Oncology Group scoring system.20 Grade 1 acute toxicity (skin erythema, dry desquamation or alopecia) was seen in 3/24 (12%) of the patients who received 8 Gy, 11/24 (46%) of patients who received 20 Gy and 22/23 (96%) patients who received 40 Gy. No acute toxicity greater than grade 1 was seen. Late toxicity occurred only in the 40 Gy group (6/23 patients) but did not exceed grade 1 (slight hyperpigmentation or alopecia). In a large retrospective case series of 621 evaluable patients the frequency of grade 1, grade 2 and grade 3 skin reactions was 7%, 69% and 23-4%, respectively.22
Harrison et al. developed a subjective four-point grading system to assess pigmentation in the normal skin surrounding lesions following irradiation as part of overall cosmesis.21 The scoring system graded cosmesis from grade 0 (no evidence of pigmentation) to grade 3 (severe skin pigmentation or telangiectasia). Of the 172 randomised lesions, cosmesis grade 0 or 1 was found in 87% of those who received a single fraction and 90% of those who received four fractions, a non-significant difference.
Was this article helpful?
Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.