Only two RCTs had precise data on adverse events. Pain or blistering was reported by 64/100 (64%) of participants treated with an "aggressive" (10-second) regimen compared with 44/100 (44%) of those treated with a "gentle" (brief freeze) regimen (OR 2-26 (CI 1-28-3-99)). Five participants withdrew from the aggressive group and one from the gentle group because of pain and blistering23. Pain and/or blistering was reported in 29%, 7% and 0% of those treated at 1-, 2- and 3-week intervals, respectively (no available data for OR).27 The rate of reported adverse affects was higher with a shorter interval between treatments but this is likely to be a reporting artefact because these participants were seen sooner after each treatment.

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