Topical mechlorethamine may cause an irritant reaction and up to 40% of patients develop contact hypersensitivity. This is less common with the ointment (0-01—0-02%). The aqueous solution (10—20 mg in 40—60 ml water) is less stable than the ointment. Mechlorethamine (nitrogen mustard) is carcinogenic and secondary cutaneous malignancies (non-melanoma skin cancer) have been attributed to long-term use of topical mechlorethamine (8-6-fold and 1-8-fold increased risk for squamous cell carcinoma and basal cell carcinoma respectively). Home use is acceptable, with patients applying topical treatment overnight; however, partners should avoid contact, especially if pregnant. Appropriate protection for staff members applying topical therapy in the hospital setting is required although no toxic effects have been reported.20
Was this article helpful?
Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.