Drawbacks

Topical mechlorethamine may cause an irritant reaction and up to 40% of patients develop contact hypersensitivity. This is less common with the ointment (0-01—0-02%). The aqueous solution (10—20 mg in 40—60 ml water) is less stable than the ointment. Mechlorethamine (nitrogen mustard) is carcinogenic and secondary cutaneous malignancies (non-melanoma skin cancer) have been attributed to long-term use of topical mechlorethamine (8-6-fold and 1-8-fold increased risk for squamous cell carcinoma and basal cell carcinoma respectively). Home use is acceptable, with patients applying topical treatment overnight; however, partners should avoid contact, especially if pregnant. Appropriate protection for staff members applying topical therapy in the hospital setting is required although no toxic effects have been reported.20

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Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

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