Minoxidil causes redness and itching of the scalp skin in approximately 5% of women. In most women this effect seems to be non-specific irritation by polyethylene glycol or other solvents; in some, however, specific type IV allergy against minoxidil is possible. Patients sometimes attribute specific systemic effects such as hypotension or increase of heart rate to minoxidil, but the very low serum concentrations of minoxidil after twice-daily topical administration make this implausible.

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