Calcipotriol monotherapy causes more irritation than potent topical corticosteroids (number needed to harm (NNH) 10, 95% confidence intervals (CI) 6 to 34).22 Perilesional irritation from calcipotriol has been reported in as many as 25% of people, the face and flexures being most susceptible. Hypercalciuria is a dose-related side-effect of therapy, and application of large amounts of calcipotriol can cause hypercalcaemia. To avoid these problems it is recommended that patients should not use more than 100 g 0-05% calcipotriol cream or ointment per week.

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