None were reported.
Most studies did not evaluate the effectiveness of tetracycline alone, but rather in combination with other topical and oral preparations. Much of the available evidence is methodologically flawed. For example, none of the studies adequately defined the term "complete clearing" and results were not evaluated statistically. Before consultation, many of the patients in the case series were treated unsuccessfully with potent topical steroids, therefore allowing for no wash-out period. In addition, some studies did not focus only on perioral dermatitis but included other conditions such as rosacea and rosacea-like dermatitis. Only one double-blind RCT compared oral tetracyline, 250 mg twice daily, with 1% metronidazole cream.
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Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.