We found four RCTs evaluating steroid/antibiotic combinations for clinically infected atopic eczema1315-17 (Table 17.6).
The study by Thaci et a/.15 showed superior benefit of both betamethasone/fusidic acid ointment and cream over vehicle alone, with no significant difference between cream and ointment.
Two RCTs found no significant difference in clinical signs or symptoms when betamethasone valerate/fusidic acid16 or betamethasone/ gentamicin13 were compared with topical steroid alone.
There was no significant difference between 0-1% betamethasone/2% fusidic acid and 0-1% betamethasone/0-5% neomycin in terms of clinical efficacy or ability to eradicate S. aureus.1
One further RCT was located that has evaluated topical steroid/antibiotic treatment for non-clinically infected atopic eczema. In this study, 2% fusidic acid/1% hydrocortisone showed no clear benefit over 1% hydrocortisone alone in reducing atopic eczema activity, but it was significantly better at reducing S. aureus.12
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