No RCTs have compared the effectiveness of cryotherapy with other treatments. Several case series have examined the cure rate of cryosurgery in SCC. Over an 18-year period, Zacarian41 treated 4228 skin cancers with cryotherapy, which included 203 SCC lesions. He noted a 97% cure rate in a follow up ranging from less than 3 months to over 10 years. Most recurrences (87%) occurred in the first 3 years. Zacarian further noted a healing time that ranged from 4 to 10 weeks. Kuflik42 found a 96% 5-year cure rate for 52 SCC lesions. Holt10 reported 34 SCC lesions treated with cryotherapy and a 97% cure after follow up ranging from 6 months to 5-5 years.

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