Although MMS is frequently used in the treatment of SCC, there are no RCTs comparing MMS with other treatments.

Mohs reported a 5-year cure rate of 95% for primary SCC.32 In a case-series analysis, Rowe et al. found that MMS resulted in a lower rate of local recurrence compared with other treatment modalities.27 Holmkvist and Roenigk report a cure rate for primary SCC of the lip of 92% after MMS for 50 patients in an 2-5 year average follow up.33 Lawrence and Cottel reported only three local recurrences of SCC in 44 patients with perineural invasion treated by MMS in a 1-year follow up, and further noted that predicted survival was higher than previously published survival rates for surgical excision.34-36

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